Precision-formulated for the dietary management of chronic inflammation and systemic inflammatory balance.
ACEND-CI is a Medical Food coded by the U.S. Department of Health and Human Services under HCPCS code #A9153
Targets IL-6, TNF-α, hsCRP, and NF-κB signaling
Polyphenols and bioactives for whole-body cellular resilience
Practitioner-formulated, clinical-grade dosing
Clean, non-GMO, and third-party tested
Addresses multiple interconnected inflammatory pathways, biomarkers, and systems beyond those listed.
Non-GMO
Gluten-free Certified
FODMAP CERTIFIED
Halal Certified
SQF Certified
NSF cGMP
PUBLIC BENEFIT COMPANY
PLASTIC NEUTRAL
THIRD-PARTY TESTED
Non-GMO
Gluten-free Certified
FODMAP CERTIFIED
Halal Certified
SQF Certified
NSF cGMP
PUBLIC BENEFIT COMPANY
PLASTIC NEUTRAL
THIRD-PARTY TESTED
Non-GMO
Gluten-free Certified
FODMAP CERTIFIED
Halal Certified
SQF Certified
NSF cGMP
PUBLIC BENEFIT COMPANY
PLASTIC NEUTRAL
THIRD-PARTY TESTED
Designed for consistent, daily use as a foundational protocol
Multiple biomarkers, pathways, and systems associated with chronic inflammation
Polyphenols + gut support + micronutrient foundation
Synergistic delivery of bioactives and bioavailable ingredients
Clinically informed ingredients with complementary mechanisms—selected for defined inflammatory roles and synergistic benefits. ACEND-CI prioritizes pathway appropriate bioactives, coherent formulation logic and dose discipline.
Chronic inflammation is rarely confined to one tissue or symptom. It reflects a whole-body imbalance in immune signaling, metabolic regulation, vascular integrity, gut-barrier function, and cellular repair.
ACEND-CI was designed as the foundational ACEND formula—built to support inflammatory balance across interconnected pathways using clinically informed nutrition.
35 evidence-based ingredients with complementary mechanisms
pre/probiotic + barrier-support intent at a major inflammatory interface
Built for long-term use—not ‘mega-dosed’ supplement blends
Third-party testing for raw materials and finished goods
Supports key inflammatory signals and upstream regulators (oxidative stress balance, immune tone)
DHHS recognition with an awarded HCPCS code
Sourced, tested, certified and designed with a commitment to creating the most efficacious, safe and sustainable products.
Most people think of polyphenols as antioxidants and are unaware of their true pleiotropic nature. Polyphenols also act as selective fuel for beneficial gut microbes. A portion of polyphenols reach the colon, where microbes metabolize them into bioactive compounds—supporting microbial balance, gut barrier integrity, and more stable immune signaling. This gut–immune relationship is one reason polyphenols are foundational in systems-based inflammation support.
ACEND-CI is designed with polyphenol diversity plus prebiotic fiber and probiotics to support the gut–immune interface.
The timeline below reflects customer-reported experiences and practitioner feedback. It is not based on completed clinical trial outcomes for ACEND-CI. Individual experiences vary.
Reduction In Achy Joints
Early relief in achy joints and underlying musculoskeletal discomfort, along with improved day-to-day energy and less fatigue.
Improved Digestion
Easier digestion, less bloating, improved regularity, and continued easing of inflammatory aches and stiffness
Improved Mobility
Improved Mobility and Sleep. Improved mobility and daily function (e.g., feeling steadier and more comfortable with grip and movement), with more consistent recovery.
Significant Reduction Of Aches
Aches and pains are substantially reduced; some report reduced reliance on NSAID use. Digestive patterns may feel more stable and regular.
Improvement In Microcirculation
Improved comfort in extremities and less perceived swelling, consistent with improved micro-circulation support and reduced inflammatory tone.
Improved Range Of Motion
Range of motion and recovery improved, especially when paired with stretching or gentle strength work, plus better sleep quality and steadier energy.
Improvement In Overall Quality Of Life
Users report an increase in overall quality of life, with less aches and pains, joint mobility, more energy and gut function.
Consistency is essential for long-term inflammatory balance and systemic improvements
Cancel or pause anytime
ACEND-CI influences a broad network of biomarkers, pathways, and physiological systems associated with chronic inflammation.
ACEND-CI is a medical food designed for the dietary management of chronic inflammation, intended to take under medical supervision.
DHHS-recognized medical food with an awarded HCPCS code, reflecting its clinical classification and supervised nutritional use.
Consult a healthcare professional if pregnant, nursing, managing a medical condition, or taking prescription medications.
You have questions? We have answers. Visit our FAQ page to review answers to the most common questions. If you don’t see an answer to your question, contact us, we love hearing from our customers.
CI-1 is our first released apex formula, containing over 35 evidence-based ingredients, for the broad dietary support of chronic inflammatory conditions. We are building additional condition-specific formulas and will introduce them as they complete production and release readiness
Yes. CI-1 offers subscription options so you can maintain consistent daily intake without reordering each month.
Yes, adding ACEND-CI to milk, your favorite juice or smoothie helps keep the flavor interesting. In fact, we receive feedback from customers that adding a little milk or cream to their water-based ACEND-CI beverage makes it taste like a “creamsicle”.
Launch timing varies by formula. You can join the list on this page to receive release updates.
Many people experience overlapping drivers of inflammation. CI-1 is designed as a foundational formula that support systemic chronic inflammation, which is common across many conditions. For condition-specific needs, additional formulas will be introduced over time.
